http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#Head http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#assertion http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#provenance http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#pubinfo http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#assertion http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_2 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0005525 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7989 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0007726 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-diseases/tumor%20growth http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_1 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#assertion http://www.w3.org/2000/01/rdf-schema#label gtp(p(HGNC:NRAS)) -> path(SDIS:"tumor growth") http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_4 http://www.w3.org/ns/prov#value To test if activation of HRas or NRas by eNOS is required for pancreatic tumour growth, HRas or NRas were knocked down by shRNA in CFPac-1 and/or MIAPaCa-2 cells and complemented with an HRas or NRas that was engineered to be resistant to RNAi (HRasR, NRasR) in the wild-type or C118S mutant configuration. Resultant cells were then assayed for tumour growth in mice. Positive control, scramble-treated CFPac-1 and/or MIAPaCa-2 cells readily formed tumours in mice, whereas this growth was reduced when endogenous HRas, and to a lesser degree NRas, was knocked down. This loss of tumour growth was rescued by expressing the appropriate wild-type HRas or NRas, but not the C118S nitrosylation mutants (Fig. 4e, f and Supplementary Figs 11–13 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18344980 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18344980 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#_4 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04#pubinfo http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04 http://purl.org/dc/terms/created 2014-07-03T14:33:18.640+02:00 http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RALWLYFYW89YcBSzNR7zAp8KkxagMfK1zMdxgAJ3dkr04 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234