http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#Head http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#assertion http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#provenance http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#pubinfo http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#assertion http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:88439 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/Diacylglycerol http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_1 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Cntf) -> a(SCHEM:Diacylglycerol) http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_3 http://www.w3.org/ns/prov#value The intracellular mechanisms through which two trophic factors, ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF), regulate cholinergic development were examined in sympathetic neuron cultures. Treatment with CNTF or LIF increased levels of choline acetyltransferase (ChAT) activity by 375 and 350%, respectively. However, in neuronal cultures depleted of protein kinase C (PKC) activity by chronic phorbol ester treatment, neither CNTF nor LIF elevated ChAT activity. Further, the stimulation of ChAT due to increased cell density was not observed in PKC-depleted sympathetic neurons. The inhibition of CNTF-stimulated ChAT by phorbol ester occurred in a dose-dependent manner and chronic phorbol ester treatments did not alter the levels of the catecholamine biosynthetic enzyme tyrosine hydroxylase. Moreover, increased levels of diacylglycerol, an endogenous activator of PKC, were observed in sympathetic neurons treated with CNTF. However, neither CNTF nor LIF stimulated the hydrolysis of phosphatidylinositol 4,5-bisphosphate. These observations suggest that a common PKC-dependent pathway, which is independent of phosphatidylinositol 4,5-bisphosphate hydrolysis, mediates the cholinergic stimulating effects of CNTF, LIF, and cell-cell contact in cultured sympathetic neurons. http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8380192 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8380192 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#_3 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g#pubinfo http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g http://purl.org/dc/terms/created 2014-07-03T14:33:49.693+02:00 http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RALEajtfuNGYZUrpXyvEflY6kOD39L3XJpFj0_R6qDN0g http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234