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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#_4 http://www.w3.org/ns/prov#value Our previous studies showed that etoposide may induce an apoptotic signaling pathway similar to that induced by ceramide.15,16 We thus determined the generation of ceramide in etoposide-treated Jurkat T cells. Results showed that etoposide induced ceramide generation within 1 hour (Figure 4A). Treatment with fumonisin B1, an inhibitor of ceramide synthase, and myriocin, an inhibitor of serine palmitoyl transferase {SPTLC1, SPTLC2}, but not chlorpromazine and desprimine, inhibitors of acid sphingomyelinase, inhibited etoposide-induced cell apoptosis (Figure 4B), thus indicating a requirement for de novo ceramide generation. Furthermore, we demonstrated the increased expression of Txnip by etoposide (Figure 4C) http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18270325 http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18270325 http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#_4 http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8#pubinfo http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8 http://purl.org/dc/terms/created 2014-07-03T14:33:17.412+02:00 http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RALA1k5j8jbsoE414ZTTaMi4NVVZTxnCk80o9L45O5rL8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234