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[Deficient fibrillin-1 is thought to result in the failed sequestration of transforming growth factor ? (TGF?) and subsequent activation of the TGF? signaling pathway, suggesting that the circulating TGF? level may be elevated in MFS, although its accurate measurement is complex due to ex vivo release from platelet stores upon platelet activation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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