@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v3.0.0/void/> .

dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_head {
  this: np:hasAssertion dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_assertion;
    np:hasProvenance dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_provenance;
    np:hasPublicationInfo dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_assertion a np:Assertion .
  
  dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_provenance a np:Provenance .
  
  dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_assertion {
  miriam-gene:3856 a ncit:C16612 .
  
  lld:C0006826 a ncit:C7057 .
  
  dgn-gda:DGNe86920ac7497f60cd3cdc5177dc65728 sio:SIO_000628 miriam-gene:3856, lld:C0006826;
    a sio:SIO_001121 .
}

dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_provenance {
  dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_assertion dcterms:description
      "[After treatment of the three cancer cell lines with different doses of the (pro)enzymes for up to 7 days, we observed (i) growth inhibition in a dose-dependent manner, (ii) enhanced expression of β-catenin and E-cadherin and decreased expression of several epithelial-mesenchymal transition (EMT)-associated genes, such as Vimentin, Snail and Slug, (iii) differentiation of Caco-2 cells, including the appearance of cell-specific differentiated structures such as microvilli and tight junctions, the acquisition of a more regular polygonal morphology, and an increased expression of the intestinal differentiation markers alkaline phosphatase and cytokeratin 8, and (iv) differentiation of Panc1 cells, including the formation of cell aggregates, an increment on lamellar bodies and an increased expression of the pancreatic differentiation markers glucagon and insulin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:23677639;
    prov:wasDerivedFrom dgn-void:befree-20150227;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20150227 pav:importedOn "2015-02-27"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP528766.RAKy043DGSOBdSdHDgNHX1eP7MLaIikmwuwYhKy1ZgqdI130_publicationInfo {
  this: dcterms:created "2015-08-25T14:42:52+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v3.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v3.0.0" .
}