@prefix dcterms: .
@prefix this: .
@prefix sub: .
@prefix beldoc: .
@prefix rdfs: .
@prefix xsd: .
@prefix dce: .
@prefix pav: .
@prefix np: .
@prefix prov: .
@prefix Protein: .
@prefix hgnc: .
@prefix geneProductOf: .
@prefix hasPart: .
@prefix ProteinComplex: .
@prefix species: .
@prefix occursIn: .
@prefix pubmed: .
@prefix orcid: .
sub:Head {
this: np:hasAssertion sub:assertion;
np:hasProvenance sub:provenance;
np:hasPublicationInfo sub:pubinfo;
a np:Nanopublication .
}
sub:assertion {
sub:_1 hasPart: hgnc:12680, sub:_2;
occursIn: species:9606;
a ProteinComplex: .
sub:_2 geneProductOf: hgnc:2514;
a Protein: .
sub:assertion rdfs:label "complex(p(HGNC:CTNNB1),g(HGNC:VEGFA))" .
}
sub:provenance {
beldoc: dce:description "Approximately 61,000 statements.";
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
dce:title "BEL Framework Large Corpus Document";
pav:authoredBy sub:_4;
pav:version "1.4" .
sub:_3 prov:value "To determine whether activation of the Wnt pathway directly up-regulates the VEGF promoter, an oncogenic ß-cateninS37A was transfected with the 2.8-kb VEGF-pGL2 reporter into HeLa cells. A critical serine phosphorylation site at amino acid 37 that ordinarily targets ß-catenin for degradation has been mutated (10) . Fig. 1D. Citation illustrates a linear dose response to the effects of ß-cateninS37A. The peak response was observed when 1.25 µg of expression vector was cotransfected with 0.75 µg of reporter vector, resulting in a >30-fold stimulation of VEGF promoter activity. In independent studies, HeLa cells were treated with 25 mM LiCl, an inhibitor of GSK-3ß kinase activity. GSK-3ß is a negative regulator of Wnt signaling, and inhibiting GSK-3ß with LiCl resulted in a 2.2-fold increase in VEGF promoter activity. Collectively, these findings indicate that activation of Wnt signaling up-regulates VEGF expression in colonic neoplasia. (from full text) ";
prov:wasQuotedFrom pubmed:11507052 .
sub:_4 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:11507052;
prov:wasDerivedFrom beldoc:, sub:_3 .
}
sub:pubinfo {
this: dcterms:created "2014-07-03T14:29:57.860+02:00"^^xsd:dateTime;
pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}