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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAKfbPsftHvVfIQRAJL2LHqOQL8LYp85P82lBw5KyHkxU#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAKfbPsftHvVfIQRAJL2LHqOQL8LYp85P82lBw5KyHkxU#_6 http://purl.org/dc/elements/1.1/identifier Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 10 http://www.tkuhn.ch/bel2nanopub/RAKfbPsftHvVfIQRAJL2LHqOQL8LYp85P82lBw5KyHkxU#_6 http://purl.org/dc/elements/1.1/title Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 10 http://www.tkuhn.ch/bel2nanopub/RAKfbPsftHvVfIQRAJL2LHqOQL8LYp85P82lBw5KyHkxU#_6 http://purl.org/dc/elements/1.1/type Book http://www.tkuhn.ch/bel2nanopub/RAKfbPsftHvVfIQRAJL2LHqOQL8LYp85P82lBw5KyHkxU#_7 http://www.w3.org/ns/prov#value The insulin receptor tyrosine kinase is capable of inducing phosphorylation and activation of the cGMP-inhibited phosphodiesterase and several protein serine phosphatases (most likely protein phosphatases 1, 2A, and 2C). Phosphatidyl inositol 3-kinase A has been demonstrated as an essential component in the insulin-stimulated activation of the cGMP-inhibited phosphodiesterase but, as previously mentioned, Protein kinase A can also fullfill this this role in the absence of insulin. 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