@prefix this: <http://bio2rdf.org/drugbank:DB09001_nanopub.RAKZ8Bd9tGEnNrmkR7-jNNPVHrYIjEBOtFhlqmdF4xujY> .
@prefix sub: <http://bio2rdf.org/drugbank:DB09001_nanopub.RAKZ8Bd9tGEnNrmkR7-jNNPVHrYIjEBOtFhlqmdF4xujY#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix pav: <http://purl.org/pav/> .
@prefix orcid: <http://orcid.org/> .
@prefix codebase: <https://github.com/tkuhn/bio2rdf2nanopub> .
@prefix version: <https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349> .
@prefix instance: <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB> .
@prefix process: <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix v: <http://bio2rdf.org/bio2rdf_vocabulary:> .
@prefix d: <http://bio2rdf.org/drugbank:> .
@prefix dv: <http://bio2rdf.org/drugbank_vocabulary:> .
@prefix dr: <http://bio2rdf.org/drugbank_resource:> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:publicationInfo;
    a np:Nanopublication .
}

sub:assertion {
  d:DB09001 v:identifier "DB09001";
    v:namespace "drugbank";
    v:uri "http://bio2rdf.org/drugbank:DB09001";
    v:x-identifiers.org <http://identifiers.org/drugbank/DB09001>;
    dv:drugbank-id "DB09001";
    dv:x-cas <http://bio2rdf.org/cas:4388-82-3>;
    dct:description """Barbexaclone, a salt compound of propylhexedrine and phenobarbital, is a potent antiepileptic. [4] By weight, 
barbexaclone is 40% propylhexedrine and 60% phenobarbital. [2] While barbexaclone has sedative properties,
propylhexedrine has psychostimulant properties intended to offset these sedative effects. 
Pharmacokinetic studies have demonstrated that the pharmacokinetics of phenobarbital given as barbexaclone
are not affected by propylhexedrine. Several reports from Spanish and Italian literature suggest that barbexaclone 
is at least as effective as phenobarbital in adults and children, while being better tolerated and having less sedative properties.  
These reports were conducted in a small series of patients in the 1970s and 1980s, and have yet to be 
confirmed by larger controlled trials. [4] Despite the lack of controlled trials, barbexaclone was used widely in Turkey until it was discontinued in 2009. [1] 

Barbexaclone exists in 25mg and 100mg tablets. 100mg of barbexaclone is equivalent to 60mg of phenobarbital. With this difference in 
potency in mind, other pharmacokinetic considerations such as dose titration, daily dosing, and optimal plasma concentration can be considered 
the same as for the equivalent amount of phenobarbital. [4]

There has been a case of barbexaclone abuse due to the amphetamine like properties of propylhexedrine, 
although the comparative abuse potential is much lower than amphetamine. [2]"""@en;
    dct:identifier "drugbank:DB09001";
    dct:title "Barbexaclone"@en;
    a dv:Drug;
    rdfs:label "Barbexaclone [drugbank:DB09001]"@en;
    rdfs:seeAlso <http://www.drugbank.ca/drugs/DB09001>, <http://www.drugs.com/international/barbexaclone.html> .
}

sub:provenance {
  sub:assertion prov:wasDerivedFrom <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> .
  
  dr:bio2rdf.dataset.drugbank.R3 dcat:distribution <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> .
  
  <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> dct:created "2015-01-09T17:00:50-05:00"^^xsd:dateTime;
    prov:wasDerivedFrom <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00> .
  
  <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00>
    pav:retrievedOn "2014-11-12T07:57:03-05:00"^^xsd:dateTime;
    prov:wasDerivedFrom <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> .
  
  <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> prov:wasAttributedTo
      <http://drugbank.ca> .
}

sub:publicationInfo {
  sub:signature.MCwCFBUPkXZhYgLd npx:hasPublicKey "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";
    npx:hasSignature "MCwCFBUPkXZhYgLd3sb4VKh96JgfkvkDAhR7PGP9JZaoNzwrsoHcbsRLWFDNMg==";
    npx:signedBy instance: .
  
  this: dct:created "2018-03-30T11:11:06.868+02:00"^^xsd:dateTime;
    dct:license <https://creativecommons.org/licenses/by-nc/4.0/>;
    npx:hasSignatureElement sub:signature.MCwCFBUPkXZhYgLd;
    prov:wasGeneratedBy process: .
  
  instance: prov:specializationOf codebase:;
    prov:wasAttributedTo orcid:0000-0002-1267-0234 .
  
  process: dct:identifier "7720f136-841b-4851-a6e4-ad20a409a475";
    prov:used version:;
    prov:wasAssociatedWith instance:;
    prov:wasStartedBy orcid:0000-0002-1267-0234 .
  
  version: dct:isVersionOf codebase:;
    pav:version "eda7951a5f6c622c5d2132f50c3093138484a349";
    prov:wasAttributedTo orcid:0000-0002-1267-0234 .
}