. . . . "DB09001" . "drugbank" . "http://bio2rdf.org/drugbank:DB09001" . . "DB09001" . . "Barbexaclone, a salt compound of propylhexedrine and phenobarbital, is a potent antiepileptic. [4] By weight, \nbarbexaclone is 40% propylhexedrine and 60% phenobarbital. [2] While barbexaclone has sedative properties,\npropylhexedrine has psychostimulant properties intended to offset these sedative effects. \nPharmacokinetic studies have demonstrated that the pharmacokinetics of phenobarbital given as barbexaclone\nare not affected by propylhexedrine. Several reports from Spanish and Italian literature suggest that barbexaclone \nis at least as effective as phenobarbital in adults and children, while being better tolerated and having less sedative properties. \nThese reports were conducted in a small series of patients in the 1970s and 1980s, and have yet to be \nconfirmed by larger controlled trials. [4] Despite the lack of controlled trials, barbexaclone was used widely in Turkey until it was discontinued in 2009. [1] \n\nBarbexaclone exists in 25mg and 100mg tablets. 100mg of barbexaclone is equivalent to 60mg of phenobarbital. With this difference in \npotency in mind, other pharmacokinetic considerations such as dose titration, daily dosing, and optimal plasma concentration can be considered \nthe same as for the equivalent amount of phenobarbital. [4]\n\nThere has been a case of barbexaclone abuse due to the amphetamine like properties of propylhexedrine, \nalthough the comparative abuse potential is much lower than amphetamine. [2]"@en . "drugbank:DB09001" . "Barbexaclone"@en . . "Barbexaclone [drugbank:DB09001]"@en . . . . . "2015-01-09T17:00:50-05:00"^^ . . "2014-11-12T07:57:03-05:00"^^ . . . "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" . "MCwCFBUPkXZhYgLd3sb4VKh96JgfkvkDAhR7PGP9JZaoNzwrsoHcbsRLWFDNMg==" . . "2018-03-30T11:11:06.868+02:00"^^ . . . . . . "7720f136-841b-4851-a6e4-ad20a409a475" . . . . . "eda7951a5f6c622c5d2132f50c3093138484a349" . .