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<http://bio2rdf.org/drugbank:DB05463_nanopub.RAKQcABa5ovsWRY0GBf-afUuDajygcV8WPzZtDLen36uw> <http://www.nanopub.org/nschema#hasProvenance> <http://bio2rdf.org/drugbank:DB05463_nanopub.RAKQcABa5ovsWRY0GBf-afUuDajygcV8WPzZtDLen36uw#provenance> <http://bio2rdf.org/drugbank:DB05463_nanopub.RAKQcABa5ovsWRY0GBf-afUuDajygcV8WPzZtDLen36uw#head> .
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<http://bio2rdf.org/drugbank:DB05463> <http://purl.org/dc/terms/description> "ISS 1018 is a short, synthetic, unmethylated CpG oligodeoxynucleotide (CpG ODN) with immunostimulatory activity. ISS 1018 signals through Toll-like receptor 9 (TLR9) to induce the production of immunoglobulin by B cells and interferon (IFN) -alpha, IFN-beta, interleukin-12 (IL-12), and tumor necrosis factor - alpha (TNF-alpha) by plasmacytoid dendritic cells (pDC). ISS 1018 CpG ODN promotes antigen presentation and co-stimulatory molecule expression. ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent Hepatitis B in adults. It is also being investigated in combination with rituximab for treatment of b-cell or non-hodgkin's lymphoma."@en <http://bio2rdf.org/drugbank:DB05463_nanopub.RAKQcABa5ovsWRY0GBf-afUuDajygcV8WPzZtDLen36uw#assertion> .
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