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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#_5 http://www.w3.org/ns/prov#value We report the detection of 2 different mutant ARs within the same metastatic tumour sample harvested in a patient with advanced PCa who had escaped androgen deprivation. Concomitantly to the widely described T877A mutant AR, we identified an additional double mutant AR harboring the nonsense mutation Q640Stop just downstream the DNA binding domain together with the T877A point mutation. This type of mutation, which leads to a c-terminal truncated AR, has not been described yet in PCa. Using luciferase reporter assays we demonstrated that this truncated AR exhibited constitutive transactivation properties. http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14618630 http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14618630 http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#_5 http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0 http://purl.org/dc/terms/created 2014-07-03T14:32:12.100+02:00 http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAKKlPxVGepq_eLthK1MjtP7-DzJXE5OlAco7fx3B2Rn0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234