. . . . . . . . . . . . . . "p(MGI:Socs1) -| p(MGI:Jak2,pmod(P))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Thrombopoetin (TPO) induced the phosphorylation of Jak2 in BaF3/mMpl cells. Pretreatment of BaF3/mMpl cells and mature megakaryocytes (MKs) with IFN-alpha for 4 hours before stimulation with TPO, inhibited the TPO-induced Jak2 phosphorylation. It is observed that Jak2 phosphorylation was blunted by IFN-alpha and is most consistent with the action of Socs-1 which appears responsible for impaired TPO signaling. Phosphorylation of Jak2 was reduced in the presence of TPO plus IFN-alpha to 45% than that seen in cells cultured in TPO alone. In primary murine MK cultured in TPO plus IFN-alpha, Jak2 phosphorylation was reduced to 75%, compared to cultures containing TPO alone." . . "Selventa" . . . . "2014-07-03T14:29:52.335+02:00"^^ . . .