sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Thrombopoetin (TPO) induced the phosphorylation of Jak2 in BaF3/mMpl cells. Pretreatment of BaF3/mMpl cells and mature megakaryocytes (MKs) with IFN-alpha for 4 hours before stimulation with TPO, inhibited the TPO-induced Jak2 phosphorylation. It is observed that Jak2 phosphorylation was blunted by IFN-alpha and is most consistent with the action of Socs-1 which appears responsible for impaired TPO signaling. Phosphorylation of Jak2 was reduced in the presence of TPO plus IFN-alpha to 45% than that seen in cells cultured in TPO alone. In primary murine MK cultured in TPO plus IFN-alpha, Jak2 phosphorylation was reduced to 75%, compared to cultures containing TPO alone." ;
    prov:wasQuotedFrom pubmed:10979953 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10979953 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}