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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAKEsPvJmOIFZXVrvmEgpViIfvnZ5LU1z286aAFrsB58w#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAKEsPvJmOIFZXVrvmEgpViIfvnZ5LU1z286aAFrsB58w#_5 http://www.w3.org/ns/prov#value Another prerequisite for a role of PDGF in wound healing is that cells in the wounded area express PDGF receptors. Immunohistochemical staining for PDGF receptors has revealed that fibroblasts and smooth muscle cells of resting tissues contain low levels of receptors. However, the beta -receptor is upregulated, e.g., during inflammation (384, 400, 465). Expression of beta -receptors has also been observed in epithelial cells after cutaneous injury (18), although this remains controversial (360). beta -Receptors have also been shown to be upregulated in human gingival wounds (153) and in growth-activated skin from chronic wounds and psoriatic lesions (258). Impaired wound healing in diabetic mice was found to correlate with reduced expression of PDGF A-chain and alpha-receptor (34). Clinical trials have revealed that PDGF-BB increases the healing of decubitus ulcers (391). Analyses of sections from healing human wounds showed that PDGF-BB induces fibroblast proliferation and differentiation (359). 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