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[I argue that the instability in chromosome structure and number provoked by inactivation of the breast cancer-susceptibility genes BRCA1 and BRCA2 arises from the distinct functions served by their products in DNA repair or mitosis, explains many features of cancer pathogenesis in this setting, and has important implications for treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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