http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_head http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_provenance http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://identifiers.org/ncbigene/4151 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0027819 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/resource/gda/DGNd7c72bcd2e9772fa87604c760628e5b5 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/4151 http://rdf.disgenet.org/resource/gda/DGNd7c72bcd2e9772fa87604c760628e5b5 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0027819 http://rdf.disgenet.org/resource/gda/DGNd7c72bcd2e9772fa87604c760628e5b5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_provenance http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://purl.org/dc/terms/description [In this study, we further characterize the interactions between Hb and Aβ in vitro and in vivo and report the following observations: 1) the binding of Hb to Aβ required iron-containing heme; 2) other heme-containing proteins, such as myoglobin and cytochrome C, also bound to Aβ; 3) hemin-induced cytotoxicity was reduced in neuroblastoma cells by low levels of Aβ; 4) Hb was detected in neurons and glial cells of post-mortem AD brains and was up-regulated in aging and APP/PS1 transgenic mice; 5) microinjection of human Hb into the dorsal hippocampi of the APP/PS1 transgenic mice induced the formation of an envelope-like structure composed of Aβ surrounding the Hb droplets.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/22412990 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v4.0.0/void/befree-2016 http://purl.org/pav/importedOn 2016-02-19 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v4.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/dc/terms/created 2016-05-13T12:49:03+02:00 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v4.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP967270.RAJtiBZWajkBlVnbPDE7pDix6eo2APZSoSAGoNsm6K2Io http://purl.org/pav/version v4.0.0.0 http://rdf.disgenet.org/v4.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v4.0.0