@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAJmgznuUjrc-W5U2CjvFvOy-196LKCBlyb0grvfmlvlk> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAJmgznuUjrc-W5U2CjvFvOy-196LKCBlyb0grvfmlvlk#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 belv:variantOf hgnc:4616;
    a proteinModification:, psimod:00696 .
  
  sub:_2 occursIn: obo:CL_0002328, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:18723;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:nicotine) -> p(HGNC:GSK3A,pmod(P,S,21))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "five proteins previously identified to be downstream of Akt at the time of maximal nicotinic Akt induction: a member of the forkhead transcription factor family (FKHR), GSK-3? and -3?, a ribosomal kinase (p70S6K), and a binding protein for eukaryotic translation initiation factor 4E (4EBP-1) (Figure 2b). We observed different patterns of phosphorylation induced by nicotine or NNK. Nicotine increased the phosphorylation of all downstream substrates, but phosphorylation of GSK-3? and FKHR was induced most. NNK increased phosphorylation of all downstream substrates except FKHR and had the greatest effects on phosphorylation of GSK-3? and p70S6K";
    prov:wasQuotedFrom pubmed:12511591 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12511591;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dcterms:created "2014-07-03T14:31:57.814+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}