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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#_4 http://www.w3.org/ns/prov#value We show that the N-terminal transcriptional activation function AF-1, but not the C-terminal AF-2, is necessary for the EGF response. Both the EGF-induced hyperphosphorylation and the transcriptional activation of the unliganded ER depend on a phosphorylatable serine residue at position 118. However, its phosphorylation is not sufficient and, hence, there must be other target domains or proteins which fulfill an additional requirement for EGF signaling through the ER. Using dominant-negative Ras and MAP kinase kinase (MAPK kinase) and constitutively active MAPK kinase mutants, we show that EGF activates the ER by signaling through the MAPK pathway suggesting that MAPK directly phosphorylates the critical serine 118. http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8641283 http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8641283 http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#_4 http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI http://purl.org/dc/terms/created 2014-07-03T14:33:52.098+02:00 http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAJ8xXBwrvwP5muS44b-rpcR0kgAUnjZ4zIW_W2kxHHnI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234