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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#_7 http://www.w3.org/ns/prov#value Surprisingly, the association of STAT3 with the Cdc25A promoter does not necessarily lead to transcriptional induction because this protein also functions as a transcriptional repressor of the Cdc25A gene. In coimmunoprecipitations and ChIP experiments, Rb was found to associate with STAT3 on DNA and we provide evidence that Rb binds directly to the transcription factor. Thus, we propose that Myc and STAT3 cooperate to induce the expression of Cdc25A and that their transcriptional activity is normally regulated by the Rb tumor suppressor gene. http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15677471 http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15677471 http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#_7 http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA http://purl.org/dc/terms/created 2014-07-03T14:30:31.189+02:00 http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAIuZEnVfKaZike09jEFLaYvcS75wSdsVS1xLpG2sPNHA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234