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[The genotype AG of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele G of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele T showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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