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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#_6 http://www.w3.org/ns/prov#value Since Fgf8 signals via receptor-type tyrosine kinases, and Crk family adaptor proteins transduce intracellular signals downstream of tyrosine kinases, we investigated whether Crkl mediates Fgf8 signaling. In addition to discovering genetic interactions between Crkl and Fgf8 during morphogenesis of structures affected in del22q11 syndrome, we found that Fgf8 induces tyrosine phosphorylation of FgfRs 1 and 2 and their binding to Crkl. Crkl is required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression. http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16399079 http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16399079 http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#_6 http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo http://purl.org/dc/terms/created 2014-07-03T14:30:40.884+02:00 http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAIoYGD7mfY69AYNGmFc0D8IsXLnk4sHWCmeXvDgRGtwo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234