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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#_7 http://www.w3.org/ns/prov#value Both RhoGDI and D4GDI (hereafter referred to collectively as GDIs) are cytosolic and form 1:1 complexes with Rho family GTPases, although several Rho family members have been reported to not effectively bind to GDIs (Table 1). First, they inhibit the dissociation of GDP from Rho proteins, maintaining the GTPase in an inactive form and preventing GTPase activation by GEFs (Box 1). Second, they are able to interact with the GTP-bound form of the Rho GTPase to inhibit GTP hydrolysis, blocking both intrinsic and GAP-catalyzed GTPase activity and preventing interactions with effector targets. http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15921909 http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15921909 http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#_7 http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic#pubinfo http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic http://purl.org/dc/terms/created 2014-07-03T14:30:35.772+02:00 http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAIjZDjZyw6j7rVI0ceeE4cYniAQ08mVXlzMpRFZyaDic http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234