@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_head {
  this: np:hasAssertion dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_assertion;
    np:hasProvenance dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_provenance;
    np:hasPublicationInfo dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_assertion a np:Assertion .
  
  dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_provenance a np:Provenance .
  
  dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_assertion {
  miriam-gene:3091 a ncit:C16612 .
  
  lld:C0243038 a ncit:C7057 .
  
  dgn-gda:DGN74d6cedf06739b8f286a001c3186ac79 sio:SIO_000628 miriam-gene:3091, lld:C0243038;
    a sio:SIO_001121 .
}

dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_provenance {
  dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_assertion dcterms:description
      "[We found that long-term exposure to hypoxia a) significantly inhibited lung cancer tumor growth in xenograft and orthotopic models in rats, b) significantly reduced lymphatic metastasis of the lung cancer in rats and decreased lung metastasis of Lewis lung carcinoma in mice, c) reduced lung cancer cell proliferation and cell cycle progression in vitro, d) decreased growth of the tumors from hypoxia-pretreated A549 cells, e) decreased Na+-K+ ATPase α1 expression in hypoxic lung cancer tumors, and f) increased expression of hypoxia inducible factors (HIF1α and HIF2α) but decreased microvessel density in the lung cancer tumors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:21812995;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP745171.RAIdjMr4GkL-QaSMs4zzTO5yvIQEau_DFbwqmrj6aiL8Y130_publicationInfo {
  this: dcterms:created "2014-10-02T12:39:32+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}