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Regulation of TLR protein expression by interferon-? was investigated by flow cytometry of leukocyte subsets of healthy subjects and of untreated, interferon-?-, or glatiramer acetate-treated patients with MS. Interferon-? specifically upregulated mRNA expression of TLR3, TLR7, and MyD88 and downregulated TLR9 mRNA in PBMCs of healthy donors as well as in PBMCs of patients with MS. Plasmacytoid dendritic cells (pDCs) were identified as the major cell type responding to interferon-? with increased expression of TLR7 and MyD88 protein.]. 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