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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#_3 http://www.w3.org/ns/prov#value Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes and also has multifunctional effects on some other cells in various organs. A HGF activator (HGFA) has been identified as a key enzyme that regulates the activity of HGF in vivo. Our previous studies have shown that brain astrocytes produce both proteins. Recently, HGFA inhibitor-1 (HAI-1), a novel Kunitz-type serine protease inhibitor, has been isolated. We examined HAI-1 immunolabeling in the brains of neurologically normal persons and patients with Alzheimer's disease (AD) and cerebral infarction. Furthermore, we identified the expression of the mRNA for HAI-1 by in situ hybridization histochemistry. The HAI-1 antibody stained astrocytes in the white matter of all brain tissues and was present in plasma. In AD, the intensity of HAI-1 immunolabeling was less than in the other cases. Expression of the mRNA for HAI-1 was also seen in astrocytes. The intensity of the signal for HAI-1 mRNA was similar in AD and normal control brains. These results suggest that, in human brain, secreted pro-HGF from astrocytes may be activated by HGFA and inhibited by HAI-1 on or near the astrocytic cell surface and that rapid HAI-1 consumption may occur in the white matter in AD. http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9743567 http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9743567 http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#_3 http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg http://purl.org/dc/terms/created 2014-07-03T14:34:15.079+02:00 http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAIT1KqjFY2PenJfFhSjDZyln3avcBC7MFXbmlvixigpg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234