. . . . . . . . . . . . . "a(CHEBI:nicotine) -> p(HGNC:CHRNA7)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Up-regulation of functional nAChR {alpha}7 subunits has been shown in normal human bronchial epithelial cells (NHBE) upon exposure to nicotine (10). In SCLC cell lines, up-regulation of nAChR {alpha}7 has been shown in response to NNK stimulation, with overexpression and phosphorylation of serine-threonine protein kinase Raf-1 and extracellular signal regulated kinases 1 and 2 and activation of c-myc (27), leading to increased proliferation (1, 28). " . . "Selventa" . . . . "2014-07-03T14:33:10.628+02:00"^^ . . .