@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAIHZhE4hc37tCF8DcZBcQpDOYq8YfjPcMvsai7lQGiRE> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAIHZhE4hc37tCF8DcZBcQpDOYq8YfjPcMvsai7lQGiRE#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix sfam: <http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix sdis: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-diseases/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: sfam:PRKA%20Family;
    a Protein: .
  
  sub:_3 occursIn: obo:CL_0000746, obo:UBERON_0000948, species:10090;
    rdf:object sdis:I%28f%29%20F-channel%20current;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(p(SFAM:\"PRKA Family\")) -> path(SDIS:\"I(f) F-channel current\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "20131211" .
  
  sub:_4 prov:value "Several factors can influence the activation of f-channels. ?-Adrenergic receptor activation stimulates (21) while muscarinic agonists inhibit If (129). This regulation is mediated by direct activation of f-channels by cAMP (50, 128), which facilitates channel opening (126). DiFrancesco and Tortora (128) failed to observe a direct regulation of SAN f-channels by purified protein kinase A (PKA) (128). In SAN cells, direct regulation of voltage dependence by cAMP can quantitatively account for If regulation by autonomic agonists (126). The existence of a PKA-mediated regulation of If has been suggested by Chang et al. (80) in canine Purkinje cells and in murine stem cells derived from cardiomyocytes (1). Intracellular Ca2+ have been reported to positively regulate If by either increasing current conductance (171) or by positively shifting the current voltage dependence (416). The mechanisms by which Ca2+ regulate If has not been elucidated. Inside-out patch-clamp experiments seem to exclude a direct Ca2+ effect on f-channels (540).";
    prov:wasQuotedFrom pubmed:18626064 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:18626064;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:22.699+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}