@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_head {
  this: np:hasAssertion dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_assertion;
    np:hasProvenance dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_provenance;
    np:hasPublicationInfo dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_assertion a np:Assertion .
  
  dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_provenance a np:Provenance .
  
  dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_assertion {
  miriam-gene:727897 a ncit:C16612 .
  
  lld:C0019348 a ncit:C7057 .
  
  dgn-gda:DGN89db03b0854fa3bfcd7c4cff7387eaf6 sio:SIO_000628 miriam-gene:727897, lld:C0019348;
    a sio:SIO_001121 .
}

dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_provenance {
  dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_assertion dcterms:description
      "[We report the following: (a) all five mutant HSVs were avirulent in experimental animals but were cytotoxic for human tumor cells in vitro and in vivo; (b) the gamma(1)34.5- HSV replicated in human glioma cells almost as efficiently as wild-type HSV-1(F) based on replication assays, in situ hybridization for viral DNA, and expression of infected cell protein 27; (c) capacity of mutant HSVs to kill human cells derived from glioblastoma multiforme (CH-235MG, D-37MG, D-54MG, D-65MG, U-251MG, U-373MG, and SK-MG-1), anaplastic astrocytoma (Hs-683), anaplastic glioma (U-87MG and U-138MG), gliosarcoma (D-32GS), or normal human astrocytes demonstrated that glioma cells varied in their susceptibility to HSV-mediated cytotoxicity and that cultured astrocytes were two to three orders of magnitude less susceptible to killing than were malignant glia; and (d) scid mice, which received 0.5 or 5 x 10(6) plaque-forming units of R4009, either were coinoculated at the time of intracranial transplantation with 106 U251MG or D-54MG human glioma cells or received the cells intratumorally 5 days after tumor induction and experienced significant increases in median survivals, with no histopathological indication of an infectious encephalitic process.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:9108452;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP921690.RAI6ZHCnL4nhozzgJgcGaVa6faKo4GFXjjWI8V7AO0VGA130_publicationInfo {
  this: dcterms:created "2014-10-02T12:41:25+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}