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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#_3 http://www.w3.org/ns/prov#value In sham-operated male rats, transcripts for CYP2C12 were rarely detected, but mRNA levels rose to appreciable levels within 24 hours of BDL, and CYP2C12 protein was expressed in hepatic microsomes of BDL male rats. Administration of estradiol to male rats produced a similar elevation of CYP2C12 mRNA, to values approximately 40% of female rats. It is concluded that CYP2C12 is up-regulated in male rats with cholestasis caused by BDL, while CYP2C12 protein is preserved in female rats when other microsomal proteins are decreased. These changes may be related to the increase in serum estradiol levels http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9731550 http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9731550 http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#_3 http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0 http://purl.org/dc/terms/created 2014-07-03T14:31:00.428+02:00 http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAI0Y9bU04aHhJeouBkmi2wrF_hHqqvjFzi_4N2blLTx0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234