@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAI-XCi5pcIXD7rxxn0YtaPm6Xmt_muyH9_3mv07rBbOI> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAI-XCi5pcIXD7rxxn0YtaPm6Xmt_muyH9_3mv07rBbOI#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix scomp: <http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  scomp:p85%2Fp110%20PI3Kinase%20Complex a ProteinComplex: .
  
  sub:_1 hasAgent: scomp:p85%2Fp110%20PI3Kinase%20Complex;
    a go:0016301 .
  
  sub:_2 hasAgent: sub:_3;
    a go:0016301 .
  
  sub:_3 geneProductOf: hgnc:8816;
    a Protein: .
  
  sub:_4 occursIn: obo:CL_0000097, species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(complex(SCOMP:\"p85/p110 PI3Kinase Complex\")) -> kin(p(HGNC:PDPK1))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "Downstream targets of PI3K in activated mast cells. Activation of class 1 PI3Ks generates the membrane-associated PtdInsP3 at the inner membrane, which provides inducible docking sites for pleckstrin homology (PH) domains of associating signaling molecules. The Ser/Thr kinases, PDK1 and AKT are subsequently phosphorylated and activated after Kit and Fc?RI activation. Major downstream targets of PI3K and AKT in mast cells, mTORC1, Btk, FOXO3a, and GSK3? pathways are shown (also see text) together with the specific responses in activated mast cells. Although depicted in the figure, and documented in other systems, it is not known whether AKT activation is regulated by the mTORC2 complex in mast cells. In addition, the function of GSK3? in activated mast cells still requires clarification. Whether these events are also initiated by GPCRs is currently unknown. For clarity other signaling events required for Fc?RI-and Kit-mediated responses in mast cells are not depicted in this figure. Readers are referred to recent review articles for further details of these processes [6,10].";
    prov:wasQuotedFrom pubmed:18775670 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:18775670;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:25.080+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}