@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAHwHbEVeyVAPgM3pvVPtUepYMkhMkuhf1cPXhd08jK0g> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAHwHbEVeyVAPgM3pvVPtUepYMkhMkuhf1cPXhd08jK0g#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: mgi:1354159;
    a Protein: .
  
  sub:_2 geneProductOf: mgi:2686410;
    a RNA: .
  
  sub:_3 occursIn: obo:EFO_0004037, species:10090;
    rdf:object sub:_2;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(MGI:E2f6) -| r(MGI:Gm1564)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "20131211" .
  
  sub:_4 prov:value "A relatively small number of genes was up-regulated in E2f6-/- cells when compared with wild-type control cells (data not shown). Activation of genes in E2f6-/- cells is consistent with the proposed role for E2F6 in transcriptional repression. In this study we focused on two genes that were strongly up-regulated in E2F6-deficient cells and that encode for STAG3 and SMC1{beta}, meiotic specific subunits of the cohesin complex (19–21). Both proteins are required for proper segregation of chromosomes during meiotic division. Expression of a third gene, XM_196054, was also increased in E2f6-/- cells. This cDNA encodes for a novel protein with an unknown function. To validate the array data we analyzed the expression of these genes in different MEF preparations by RT-PCR. STAG3, SMC1{beta}, and XM_196054 were undetectable in wild-type fibroblasts and strongly elevated in E2f6-/- MEFs, confirming the microarray data (Fig. 1A).";
    prov:wasQuotedFrom pubmed:16236716 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:16236716;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:51.584+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}