sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "A relatively small number of genes was up-regulated in E2f6-/- cells when compared with wild-type control cells (data not shown). Activation of genes in E2f6-/- cells is consistent with the proposed role for E2F6 in transcriptional repression. In this study we focused on two genes that were strongly up-regulated in E2F6-deficient cells and that encode for STAG3 and SMC1{beta}, meiotic specific subunits of the cohesin complex (19–21). Both proteins are required for proper segregation of chromosomes during meiotic division. Expression of a third gene, XM_196054, was also increased in E2f6-/- cells. This cDNA encodes for a novel protein with an unknown function. To validate the array data we analyzed the expression of these genes in different MEF preparations by RT-PCR. STAG3, SMC1{beta}, and XM_196054 were undetectable in wild-type fibroblasts and strongly elevated in E2f6-/- MEFs, confirming the microarray data (Fig. 1A)." ;
    prov:wasQuotedFrom pubmed:16236716 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16236716 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}