http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#Head http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#assertion http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#provenance http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#assertion http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11892 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_3 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=18080 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0002048 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_2 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_1 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:TNF) -> cat(p(HGNC:ST3GAL6)) http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_5 http://www.w3.org/ns/prov#value There is increasing evidence that inflammation may affect glycosylation and sulfation of various glycoproteins. The present study reports the effect of tumor necrosis factor alpha (TNF-alpha), a proinflammatory cytokine, on the glycosyl- and sulfotransferases of the human bronchial mucosa responsible for the biosynthesis of Lewis x epitope and of its sialylated and/or sulfated derivatives, which are expressed in human bronchial mucins. Fragments of macroscopically normal human bronchial mucosa were exposed to TNF-alpha at a concentration of 20 ng/ml. TNF-alpha was shown to increase alpha1,3-fucosyltransferase activity as well as expression of the two alpha1,3-fucosyltransferase genes expressed in the human airway, FUT3 and FUT4. It had no influence on alpha1,2-fucosyltransferase activity or FUT2 expression. It also increased alpha2,3-sialyltransferase activity and the expression of ST3Gal-III and, more importantly, ST3Gal-IV and both N-acetylglucosamine 6-O-sulfotransferase and galactose 3-O-sulfotransferase. These results are consistent with the observation of oversialylation and increased expression sialyl-Lewis x epitopes on human airway mucins secreted by patients with severe lung infection such as those with cystic fibrosis, whose airways are colonized by Pseudomonas aeruginosa. However, other cytokines may also be involved in this process. http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11679593 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11679593 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#_5 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo http://purl.org/dc/terms/created 2014-07-03T14:31:44.390+02:00 http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAHsgDoA9Sukt-Hil3iEgVmz9xWD5TU9HIDXQq_EUL5Bo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234