@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAHiArzQCYHcgfr5wMQFCYRsWzte4ZWW2VdMxNRVm4F5A> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAHiArzQCYHcgfr5wMQFCYRsWzte4ZWW2VdMxNRVm4F5A#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0042789 .
  
  sub:_2 geneProductOf: mgi:1342774;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0042789 .
  
  sub:_4 geneProductOf: mgi:99421;
    a Protein: .
  
  sub:_5 occursIn: obo:CL_0000746, species:10090;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "tscript(p(MGI:Ppargc1a)) -> tscript(p(MGI:Nfe2l1))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "20131211" .
  
  sub:_6 prov:value "PGC-1{alpha} can also interact directly with and coactivate NRF-1 on the Tfam gene promoter. Third, studies in primary cardiac myocytes in culture and in the hearts of transgenic mice have demonstrated that overexpression of PGC-1{alpha} up-regulates the expression of genes involved in mitochondrial fatty acid oxidation, most of which are PPAR{alpha} targets, in addition to NRF-1 targets (Lehman et al. 2000Go). Cardiac-specific overexpression of PGC-1{alpha} in transgenic mice leads to massive mitochondrial proliferation, ultimately resulting in cardiomyopathy and death (Lehman et al. 2000Go). Interestingly, in neonatal cardiac myocytes in culture, PGC-1{alpha} induces mitochondria that support largely coupled respiration consistent with the known ATP-generating function of this organelle in heart (Lehman et al. 2000Go). Lastly, forced expression of PGC-1{alpha} in skeletal muscle of transgenic mice triggers mitochondrial proliferation and the formation of mitochondrial-rich type I, oxidative (\\\"slow-twitch\\\") muscle fibers (Lin et al. 2002bGo). Collectively, these results indicate that PGC-1{alpha} is capable of promoting mitochondrial biogenesis through its coactivating effects on key factors such as NRF-1.";
    prov:wasQuotedFrom pubmed:15004004 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15004004;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:17.617+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}