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a(CHEBI:ceramide) -> kin(p(SFAM:"MAPK Erk1/2 Family"))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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We have previously shown that de novo-synthesized ceramide signals apoptosis in primary astrocytes via activation of the Raf-1/ERK cascade [8]. The e¡ect of AICAR on the activity of these two kinases was therefore determined. The palmitate- induced activation of ERK (Fig. 3A) and Raf-1 (Fig. 3B) was prevented by AICAR.
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2014-07-03T14:31:39.568+02:00
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