. . . . . . . . . . . . . . "p(MGI:Socs1) -| p(SFAM:\"AKT Family\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Treatment with insulin induced the phosphorylation of IRS-1 and 2 but was inhibited by overexpression of SOCS-1 and 3. But treatment with antisense AS3 and AS1 (Anti-SOCS-3 and 1) or AS3+AS1 in combination restored the phosphorylation of IRS proteins and a modest improvement in PI3-kinase and Akt activity, indicating that overexpression of SOCS-1 and 3 inhibits the insulin induced signaling and led to insulin resistance." . . "Selventa" . . . . "2014-07-03T14:32:25.285+02:00"^^ . . .