http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#Head http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#assertion http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#provenance http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#assertion http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2689 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_2 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9143 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:PHOX2B),g(HGNC:DBH)) http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_3 http://www.w3.org/ns/prov#value Phox2a and Phox2b transactivate the promoter of the gene encoding the noradrenergic biosynthetic enzyme, dopamine beta-hydroxylase (DBH), and dHAND potentiates the activity of Phox2a. In this study, we use chromatin immunoprecipitation assays to identify target genes of the Phox2 proteins and dHAND. All three proteins are bound to the DBH and PHOX2B promoter regions in SH-SY5Y neuroblastoma cells. The interaction between Phox2a and dHAND is analyzed by fluorescent anisotropy, which demonstrates that dHAND causes an eightfold increase in the affinity of Phox2a for its recognition sites on the DBH promoter region. http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16280598 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16280598 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#_3 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw http://purl.org/dc/terms/created 2014-07-03T14:32:52.461+02:00 http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAHOKrCuDAanQAecL4km6eWMsW2oGKwgr_nA5k8sU7jWw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234