@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAHK9CwgO80uaGCSo_F7rtLzuKKzMhQQZGJLNjpSbfoSo> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAHK9CwgO80uaGCSo_F7rtLzuKKzMhQQZGJLNjpSbfoSo#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix scomp: <http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  scomp:p85%2Fp110%20PI3Kinase%20Complex a ProteinComplex: .
  
  sub:_1 geneProductOf: hgnc:7997;
    a Protein: .
  
  sub:_2 hasAgent: scomp:p85%2Fp110%20PI3Kinase%20Complex;
    a go:0016301 .
  
  sub:_3 occursIn: obo:CLO_0007606, species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:NRG1) -> kin(complex(SCOMP:\"p85/p110 PI3Kinase Complex\"))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "20131211" .
  
  sub:_4 prov:value "HRG Stimulates Tyrosine Phosphorylation of beta -Catenin through the PI 3-Kinase Pathway and Its Association with HER2-- Because HRG has been shown to activate several signaling pathways (4, 5, 7, 10, 36), we next examined the nature of the signaling pathway responsible for HRG-induced beta -catenin tyrosine phosphorylation. Our results showed that the HRG-increased phosphorylation status of the immunoprecipitated beta -catenin was completely reduced by blocking the PI 3-kinase pathway by pharmacological inhibitor LY294002 (PI3K inhibitor) and only modestly reduced by inhibition of the MAP kinase pathway with the chemical inhibitor PD98059 (MEK1 inhibitor) (Fig. 2A). ";
    prov:wasQuotedFrom pubmed:11328805 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11328805;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dcterms:created "2014-07-03T14:31:41.349+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}