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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAH52g0s4ygXxx2k1hgGl4FkPQagZSCFodF8AZfHv3LMk#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAH52g0s4ygXxx2k1hgGl4FkPQagZSCFodF8AZfHv3LMk#_6 http://www.w3.org/ns/prov#value Figure 4 Anti-apoptotic brakes at the mitochondrion. Black lines represent apoptotic pathways, red lines indicate inhibition. BCL2 (B-cell leukaemia lymphoma-2) and ?B-crystallin prevent mitochondrial release of the apoptogenic factors AIF (apoptosisinducing factor), cytochrome c (cyto c), HTRA2/OMI (high temperature requirement serine protease 2) and SMAC/DIABLO (second-mitochondrial-derived activator of caspases) into the cytosol by the binding and sequestration of BAX (B-cell lymphoma 2-associated protein X) and pro-apoptic BCL2 BAX-like molecules, BAK (BCL2 agonist killer 1) and BOK (BCL2-related ovarian killer protein) in the cytosol. APC (activated protein C) might prevent AIF release by increasing BCL2 expression. BAX translocation to the outer mitochondrial membrane is prevented by HSP70 (heat shock protein 70) and its co-chaperone HSP40(DNAJL1/DNAJL2). Meanwhile, membrane depolarization is prevented by the uncoupling properties of UCP2 (uncoupling protein 2) and the free radical scavenging properties of GIF (growth inhibitory factor). 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