[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0043234" ], "http://purl.obolibrary.org/obo/BFO_0000051" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_2" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_3" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2676" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_3", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8614" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_4", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://purl.bioontology.org/ontology/MSH/D017209" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "complex(p(HGNC:DAPK3),p(HGNC:PAWR)) -> bp(MESHPP:Apoptosis)" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_6" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_5", "http://www.w3.org/ns/prov#value" : [ { "@value" : "These findings suggest that Par-4, Daxx, and ZIPK may form a ternary complex, though further work is required to verify this hypothesis. ZIPK, Daxx, and Par-4 collaborate in caspase activation and apoptosis induction. Cells transfected individually with plasmids encoding ZIPK, Par-4, or Daxx did not exhibit an increase in apoptosis at the concentrations of plasmid DNA used here (Fig. 6A). In contrast, the percentage of apoptotic cells was increased two- to threefold in cultures of cells coexpressing ZIPK with either Par-4 or Daxx (Fig. 6A). Similarly, coexpressing Daxx with Par-4 elevated the percentage of apoptotic cells by two to threefold compared to the percentage due to expression of either Daxx or Par-4 alone (Fig. 6A). The most striking increase in apoptosis, however, was achieved by expressing all three proteins together. When expressed together, ZIPK, Daxx, and Par-4 induced an approximately sixfold increase in apoptosis." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12917339" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_6", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12917339" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#_5" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:30:15.522+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAGyqcWgQnim1e8xgzxHT0a9_es2gyPnuKE4hmrY7E4zU#pubinfo" } ]