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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#_7 http://www.w3.org/ns/prov#value Using the Esx1 gene promoter as a model for a Dlx3-responsive gene, studies demonstrate two near consensus Dlx3 binding sites within the proximal 2.3 kb of the transcription start site. Interestingly, binding of Dlx3 to one of these two sites was inhibited by interaction with Smad6. Consistent with this result, expression of an Esx1 promoter luciferase reporter was increased by overexpression of Dlx3; this effect was reversed with co-expression of Smad6. Further, small interference RNA-mediated knockdown of endogenous Smad6 increased Dlx3-dependent expression of the Esx1 gene promoter. Thus, Smad6 appears to functionally interact with Dlx3, altering the ability of Dlx3 to bind target gene promoters. Smad6 appears to play a modulatory role in the regulation of Dlx3-dependent gene transcription within placental trophoblasts. http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16687405 http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16687405 http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#_7 http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc http://purl.org/dc/terms/created 2014-07-03T14:33:00.376+02:00 http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAGxO85_NfKWARmcPietpQ5xHlKtx5MJfqnLsGm0Tu3Rc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234