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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#_5 http://www.w3.org/ns/prov#value The first mutation, N841 H, is similar to previously described mutations involving amino-acid substitutions of codon 841. The other novel mutation, FLT3 K663Q, is the first AML-associated gain-of-function mutation located outside the JM and AL domains. Of note, this mutation was potently inhibited by Sunitinib (SU11248), a previously described FLT3 kinase inhibitor.Somatic mutations of FLT3 resulting in constitutive kinase activation are the most common acquired genomic abnormality found in acute myeloid leukemia (AML). The majority of these mutations are internal tandem duplications (ITD) of the juxtamembrane region (JM). In addition, a minority of cases of AML are associated with mutation of the FLT3 activation loop (AL), typically involving codons D835 and/or I836. http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16990784 http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16990784 http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#_5 http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck http://purl.org/dc/terms/created 2014-07-03T14:33:03.538+02:00 http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAGge0670VgFvbu1CE-D64pZpa-gsyC1JCzYPxCSe1pck http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234