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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#_5 http://www.w3.org/ns/prov#value In response to genotoxic stresses, E2F1 is stabilized by signals that include ATM-dependent phosphorylation. We recently demonstrated that DNA damage induces also E2F1 acetylation, which is required for its recruitment onto apoptotic gene promoters. We found that acetylation of E2F1 is, instead, required to stabilize the protein in response to doxorubicin. Finally, we report that the formation of E2F1-p300/CREB-binding protein-associated factor (P/CAF) complexes is preferentially induced in doxorubicin-treated cells, and that P/CAF acetyltransferase (HAT), but not p300 HAT activity, is required for a significant E2F1 stabilization and accumulation. http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15123636 http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15123636 http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#_5 http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8 http://purl.org/dc/terms/created 2014-07-03T14:30:23.147+02:00 http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234