@prefix dcterms: .
@prefix this: .
@prefix sub: .
@prefix beldoc: .
@prefix rdfs: .
@prefix rdf: .
@prefix xsd: .
@prefix dce: .
@prefix pav: .
@prefix np: .
@prefix belv: .
@prefix prov: .
@prefix hgnc: .
@prefix proteinModification: .
@prefix psimod: .
@prefix go: .
@prefix Protein: .
@prefix geneProductOf: .
@prefix hasAgent: .
@prefix obo: .
@prefix occursIn: .
@prefix species: .
@prefix pubmed: .
@prefix orcid: .
sub:Head {
this: np:hasAssertion sub:assertion;
np:hasProvenance sub:provenance;
np:hasPublicationInfo sub:pubinfo;
a np:Nanopublication .
}
sub:assertion {
sub:_1 belv:variantOf hgnc:6877;
a proteinModification:, psimod:00696 .
sub:_2 hasAgent: sub:_3;
a go:0016301 .
sub:_3 geneProductOf: hgnc:6877;
a Protein: .
sub:_4 occursIn: obo:UBERON_0002048, species:9606;
rdf:object sub:_2;
rdf:predicate belv:directlyIncreases;
rdf:subject sub:_1;
a rdf:Statement .
sub:assertion rdfs:label "p(HGNC:MAPK3,pmod(P,T,202)) => kin(p(HGNC:MAPK3))" .
}
sub:provenance {
beldoc: dce:description "Approximately 61,000 statements.";
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
dce:title "BEL Framework Large Corpus Document";
pav:authoredBy sub:_6;
pav:version "20131211" .
sub:_5 prov:value "A previous study by our laboratory (9) showed that emphysematous lungs express MMP-1 whereas normal adult lungs do not. To determine whether this MMP-1 expression correlated with elevated mitogen-activated protein kinase, we analyzed these same human samples for p-ERK activity. Initial experiments were performed in the absence of the specific p42/p44 (ERK) substrate to determine endogenous protein phosphorylation in normal and emphysematous lungs. No difference was detected (Fig. 5A, left). However, when specific p-ERK activity was examined, significantly higher levels were detected in lung homogenates from patients with emphysema, compared with healthy control subjects (Fig. 5A, right: 1.9 ± 0.2-fold increase above normal lung, p = 0.02). We next assessed levels of ERK in eight human lung samples. Western blot analysis revealed that emphysematous lungs expressed higher p-ERK levels than normal lungs (Fig. 5B).";
prov:wasQuotedFrom pubmed:14764579 .
sub:_6 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:14764579;
prov:wasDerivedFrom beldoc:, sub:_5 .
}
sub:pubinfo {
this: dcterms:created "2014-07-03T14:32:16.065+02:00"^^xsd:dateTime;
pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}