sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "20131211" .
  sub:_6 prov:value "The forkhead box class O (FOXO) transcription factors family members, FOXO1a and FOXO3a, are phosphorylated in an AKT-dependent manner in SCF-stimulated BMMCs [76]. FOXO3a phosphorylation leads to its proteosomal degradation following ubiquitination thereby blocking its transcriptional control of the pro-apopototic factor, Bim. SCF also induces the AKT- and MAPK-dependent phosphorylation of Bim in mouse bone marrow-derived mast cells and it has been proposed that this also leads to its proteosomal degradation [76]. Thus these observations would account for the ablity of PI3K-AKT driven pathways to promote mast cell survival." ;
    prov:wasQuotedFrom pubmed:18775670 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:18775670 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}