@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAGV5A5t7eysfPkRFZX-S22p45Xe-AM3dLPUcXwvOLB5s> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAGV5A5t7eysfPkRFZX-S22p45Xe-AM3dLPUcXwvOLB5s#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasPart: chebi:23965, sub:_2;
    a ProteinComplex: .
  
  sub:_2 geneProductOf: hgnc:3467;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0016301 .
  
  sub:_4 geneProductOf: hgnc:6877;
    a Protein: .
  
  sub:_5 occursIn: atcc:HTB-22.aspx, species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "complex(a(CHEBI:estradiol),p(HGNC:ESR1)) -> kin(p(HGNC:MAPK3))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "1.4" .
  
  sub:_6 prov:value "The results showed that transcriptional activation of the SRE by E2 was due to ERalpha activation of the MAPK pathway...The role of ERalpha  expression in mediating increased reporter gene activity was further investigated and shown to be related to enhanced ERK1/2 activation...in cells transfected with pSS and ERalpha  or HE11 (DNA binding domain deletion), E2 induced CAT activity; similar results were observed for CHO cells using pSRE (Fig. 3E), suggesting that this kinase-dependent response is not associated with nuclear ERalpha  action. ";
    prov:wasQuotedFrom pubmed:11145955 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11145955;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:53.902+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}