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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGQe0H95hkvbb32PWPEMBdEXqSStz1oBtxNCv6SqC_9U#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAGQe0H95hkvbb32PWPEMBdEXqSStz1oBtxNCv6SqC_9U#_5 http://www.w3.org/ns/prov#value In addition, Bar-Sagi and colleagues have shown that superoxide production is necessary for Rac-dependent G1 progression and cellular shape changes (Joneson and Bar-Sagi, 1998). Together, these and other observations highlight a role for ROS in growth factor signaling and mitogenesis. 2.3.2.2. HBP1 and the p47 phox gene As depicted in Fig. 5, we demonstrate that the transcriptional repressor HBP1 regulates the gene for the p47phox regulatory subunit of the NADPH oxidase. The promoter of the p47phox gene contains six tandem high-affinity HBP1 DNA binding elements at ?1243 to ?1318 bp from the transcriptional start site and which were required for repression. 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