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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#_4 http://www.w3.org/ns/prov#value High-level expression of MEK-DD alone was sufficient to induce clear cellular transformation of chicken embryo fibroblasts, which caused constitutive activation of endogenous MAPK, hyperphosphorylation of Fra-2, and elevation of fra-2 and c-jun gene expression. These results indicate that phosphorylation of Fra-2 by MAPK plays an important role in stimulating endogenous AP-1 activity in a positive autoregulation mechanism, in which phosphorylated Fra-2 induces fra-2 expression through AP-1 binding sites present in its promoter. http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10359014 http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10359014 http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#_4 http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c http://purl.org/dc/terms/created 2014-07-03T14:29:47.302+02:00 http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAGLcBlIVQ9WCElEj8YIN_67c94Sjb8E3MaP7wYn5cz_c http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234