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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#_3 http://www.w3.org/ns/prov#value At the molecular level, all cardiac Cl? channels described so far may fall into the following Cl? channel gene families: (1) the cystic fibrosis transmembrane conductance regulator (CFTR), which is a member of the adenosine triphosphate-binding cassette (ABC) transporter superfamily and may be responsible for the Cl? currents activated by protein kinase A (PKA) (I Cl,PKA), protein kinase C (PKC) (I Cl,PKC) , and extracellular ATP (I Cl,ATP) in the heart; (2) ClC-2, which is a member of the ClC voltage-gated Cl? channel superfamily and may be responsible for the hyperpolarization- and cell swelling-activated inwardly rectifying Cl? current (I Cl,ir) (Duan et al. 2000; Komukai C et al. 2002a,b); (3) ClC-3, which is also a member of the ClC voltage-gated Cl? channel superfamily and may be responsible for the volume-regulated outwardly rectifying Cl? current (I Cl,vol), including the basally activated (I Cl,b) and swelling activated (I Cl,swell) components; (4) CLCA-1, which was thought to be responsible for the Ca2+-activated Cl? current (I Cl,Ca); (5) Bestrophin, a candidate also for I Cl,Ca; and (6) TMEM16, a novel candidate for I Cl,Ca http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19171656 http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19171656 http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#_3 http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U http://purl.org/dc/terms/created 2014-07-03T14:33:32.214+02:00 http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAGFiS5bZRaTOySuMvfIvInKOpOhRUQoFO-6cfS9cVJ5U http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234