http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#Head http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#assertion http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#provenance http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#assertion http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_1 http://www.selventa.com/vocabulary/translocationFrom http://amigo.geneontology.org/amigo/term/GO:0005737 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_1 http://www.selventa.com/vocabulary/translocationOf http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_2 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_1 http://www.selventa.com/vocabulary/translocationTo http://amigo.geneontology.org/amigo/term/GO:0005886 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_2 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_3 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_2 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_4 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3236 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11920 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_5 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_6 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_6 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3573 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_7 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000182 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_7 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_5 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_1 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#assertion http://www.w3.org/2000/01/rdf-schema#label tloc(complex(p(HGNC:EGFR),p(HGNC:FAS)),GOCCID:0005737,GOCCID:0005886) -> cat(p(HGNC:FADD)) http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_9 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_8 http://www.w3.org/ns/prov#value Activated Yes rapidly associated with the epidermal growth factor receptor (EGFR), which became phosphorylated at Tyr845 and Tyr1173 but not at Tyr1045. Activated EGFR then triggered an AG1478-sensitive CD95-tyrosine phosphorylation, which was a signal for membrane targeting of the EGFR/CD95 complex, subsequent recruitment of Fas-associated death domain and caspase 8, and apoptosis induction. All of these events were significantly blunted by inhibitors of sphingomyelinase, PKCzeta, NADPH oxidases, Yes, or EGFR-tyrosine kinase activity and after protein knockdown of either p47phox, Yes, or EGFR. The data suggest that CD95L-induced apoptosis involves a sphingomyelinase- and PKCzeta-dependent activation of NADPH oxidase isoforms, which is required for Yes/EGFR/CD95 interactions as upstream events of CD95 activation. http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_8 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15917250 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_9 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15917250 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#_8 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o http://purl.org/dc/terms/created 2014-07-03T14:32:45.309+02:00 http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAGEMiN9V29xPoz_Uett7ISwlJuC4vCB1ymI2UACFsp5o http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234